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Rectum: HIV-related enteropathy. Wellcome Collection. CC0 1.0 Universal. Source: Wellcome Collection.
Rectum: HIV-related enteropathy
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HIV-related enteropathy
This is a high power view of a rectal biopsy section from an HIV-positive adult with diarrhoea. It shows apoptoses as blue (haematoxyphilic) spots in place of normal epithelial cell nuclei.
Apoptosis is a form of programmed cell death with nuclear disintegration, which does not induce an inflammatory reaction. It is possible that natural killer T-cells caused the death of these epithelial cells. (Apart for HIV disease, apoptosis is only seen in the bowel in graft-versus-host disease). H&E stain.
See also image W0043170.