Further observations on the action of [beta]-iminazolylethylamine / by H.H. Dale and P.P. Laidlaw.

  • Dale, Henry Hallett, 1875-1968.
Date:
1911
Catalogue details

Licence: In copyright

Credit: Further observations on the action of [beta]-iminazolylethylamine / by H.H. Dale and P.P. Laidlaw. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    6/22 (page 182)
    FURTHER OBSERVATIONS ON THE ACTION OF /?-IMINAZOLYLETHYL AMINE. By H. H. DALE and P. P. LAIDLAW. (From the Wellcome Physiological Research Laboratories, Herne Hill.) In a previous communication1 we described the general features of the action of /3-Iminazolylethylamine. We have now to describe and discuss certain additional and supplementary observations. I. Further observations concerning the action on the systemic blood-p'essure. In our previous paper we showed that /3-I. produces a vaso-dilator fall of systemic arterial pressure in the dog and cat, a vaso-constrictor rise in the rabbit and guinea-pig, when its action is uncomplicated by respiratory effects. We showed, on the other hand, that the flow through an isolated perfused organ of the cat or dog suffered an immediate and marked diminution when a small dose of the base was added to the defibrinated blood, diluted with Ringer’s solution, which served as perfusion fluid. The anomaly was left unexplained and it seemed of interest to examine the matter further in several directions. The action on other species. It seemed possible that the action on the blood-pressure of yet other species might throw some light on the problem. The mammalian carnivora are the only animals in which, up to the present, a vaso-dilator action of sympathetic nerves and of adrenine has been observed after injection of ergotoxine. We find, however, that the monkey and the fowl respond to intravenous injection of /3-I. with typical vaso-dilator depressor effects. Fig. 1 shows the expansion of the arm accompanying the fall of carotid pressure in 1 This Journal, xlx. p. 318. 1910.