Volume 2

The haemolytic anaemias, congenital and acquired / by J.V. Dacie.

  • Dacie, John V. (John Vivian), Sir.
Date:
1960-1967
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: The haemolytic anaemias, congenital and acquired / by J.V. Dacie. Source: Wellcome Collection.

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    WARM ANTIBODIES COLD ANTIBODIES {@xe) °o Fic. 130. Osmotic-fragility data in 22 patients suffering from auto- immune hemolytic anemia of the warm-antibody type, in an active phase of their disease, and in five patients with auto- immune hemolytic anzmia of the cold-antibody type, also in an active phase of their disease. The saline concentrations causing 1% (top thin horizontal bar), 50% (thick horizontal bar) and 100% (bottom thin hori- zontal bar) lysis are recorded. + denotes > 1% lysis. The upper and lower thin horizontal lines represent the normal upper limit for initial (1%) hemolysis and the normal lower limit for complete (100%) haemolysis, respectively. The two double horizontal lines represent the upper and lower limits for 50% hemolysis (MCF). Osmotic Fragility after 24 hours’ Incubation at 37° C, Increases in osmotic fragility, often but not invariably greater than normal, are produced by incubating the blood of patients with auto-immune hemolytic anemia for 24 hours at 37° C. Selwyn (1953) studied five patients with the warm-antibody type of disease; in three of them the increase in osmotic fragility exceed- ed that of incubated normal blood. It seems unlikely, however, that study of the changes in fragility produced by incubating blood from patients with auto-immune hemolytic anemia will have the practical application in diagnosis that it has in hereditary sphero- eytosis. Young and Miller (1958a) also found that the increases