The record of pharmacy and therapeutics : being an account of improved pharmaceutical preparations, recently-introduced remedies, and a catalogue of unadulterated drugs & chemicals of the General Apothecaries Company (Limited), 49, Berners Street, Oxford Street, London.

  • General Apothecaries Company (London, England)
Date:
1856
Catalogue details

Licence: Public Domain Mark

Credit: The record of pharmacy and therapeutics : being an account of improved pharmaceutical preparations, recently-introduced remedies, and a catalogue of unadulterated drugs & chemicals of the General Apothecaries Company (Limited), 49, Berners Street, Oxford Street, London. Source: Wellcome Collection.

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    3. Sulphate of Quinoidine. Liq. Quinoidince Sulph. 3s. 6d. per oz. (bottles included). Dose, 5 minims and upwards. This preparation is believed, on good evidence, to be superior to sulphate of quinine, as an antiperiodic, against fevers, and as a tonic, and also as a prophylactic, effectually preventing the access of fever, and other effects of malaria, when taken by persons exposed to miasmata. Dr. Pereira has stated, and he expresses the combined testimony of the profession, that sulphate of quinine does not fully contain, or represent, the medicinal virtues of cinchona bark. This therapeutic fact is of great importance. It is readily explained, although, for reasons chiefly commercial, it has been little noticed. When the disulphate of quinine is crystallized from the solvents used to extract it from bark, a mother liquor is left, which being evaporated, yields a resin-like substance, uncrystallizable, but soluble in acids, and neutralizing them, with the strongly-marked flavour and other properties of the bark. To this substance the name quinoidine was applied. Many cursory but very imperfect chemical exa¬ minations of it were made, but beyond the fact that it was a group of organic bases nothing definite was made out. The manufacturers of sulphate of quinine laid it aside until a very large quantity had accumulated. In the year 1816 Professor Liebig published a statement that it was nothing more nor less than quinine in an amorphous, or uncrystalline state, bearing the same relation to the crystalline that treacle bears to sugar. The ground for this opinion was, that when treated with caustic potash, and subjected to distillation, it yielded a product termed Quinoiline—a product also of the same process pursued