Anaemia / by J.H. Bryant.

  • Bryant, John Henry.
Date:
1901
Catalogue details

Licence: In copyright

Credit: Anaemia / by J.H. Bryant. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    The macrocytes may measure as much as 20 /u, their average size is 10 fj, microcytes may measure 5 fx or even less. In addition to the alteration in size, there is usually marked poikilocytosis or alteration in the shape of the corpuscles, pear, battledore, sausage and horse- shoe shape forms being visible. In a large number of cases nucleated red blood corpuscles are found, and they also vary in number and in size and form. Three varieties are described and they are termed normo-blasts, megalo- blasts and micro-blasts. The normoblasts are of the size of the normal non-nucleated red corpuscles. They usually contain one nucleus but may possess occasionally from two to four. The nucleus stains deeply with nuclear stains and occupies the greater part of the corpuscle. The nucleus stains much deeper than the nuclei of the white corpuscles. Free nuclei may be recognised in the films by their remarkable affinity for nuclear stains. The protoplasm of the normo- blast usually presents a pure haemoglobin colour. The megaloblasts are much larger and are from two to four times the size of normal red blood discs. Their protoplasm is usually lighter in colour. The nuclei are larger than the normoblast nuclei but do not stain so deeply. Very large megaloblasts are called gigantoblasts. Microblasts are not usually present in the disease, they may be found in cases of anaemia due to severe haemorrhage. It