Inborn errors of metabolism: the Croonian lectures delivered before the Royal College of Physicians of London, in June, 1908 / by Archibald E. Garrod.

  • Garrod, Archibald E. (Archibald Edward), Sir, 1857-1936.
Date:
1909
Catalogue details

Licence: In copyright

Credit: Inborn errors of metabolism: the Croonian lectures delivered before the Royal College of Physicians of London, in June, 1908 / by Archibald E. Garrod. Source: Wellcome Collection.

Provider: This material has been provided by Royal College of Physicians, London. The original may be consulted at Royal College of Physicians, London.

    106/184 (page 94)
    it. Goldmaim’s investigations leave no doubt that the excretion of mercapturic acid, which follows the administration of halogen-benzenes to dogs, is at the expense of the sulphates of the urine and not at that of the neutral sulphur. In other words, the cystin which is in combination in the mercap- turic acid is some of that which in ordinary circum- stances would have been fully burnt to sulphuric acid. However, Blum states that when an experimental cystinuria is induced in dogs with bihary fistulas, presumably by the halogen-benzene method, although this is not stated, the taurin disappears almost completely from their bile, and this would suggest that the mercapturic cystin is that which ordinarily goes to form taurin. If this be so the inference is not to be avoided that under normal conditions the sulphur of taurin is mainly excreted as sulphate. However, there is not a httle evidence which points in a contrary direction and which tends to show that the taurin sulphur is excreted as neutral sulphur. Thus Salkowski found that in dogs, and in man also, taurin introduced into the stomach does not increase the output of sulphates, but is largely excreted as taurin-carbamic acid. In rabbits, on the other hand, and probably in the vegetivora in general, the administration of taurin by the mouth leads to an increase of the urinary sulphates. Kunkel’s®® Zeitschrift fiir physiologische Ghemie,1S85, vol. ix, p. 260. La Semaine Medicale, 1Q06, vol. x^xvi, p. 554. Virchow's Archiv, 1877, vol. Iviii, p. 460. Archiv fiir die gesammte Physiologic (Pfliiger’s), 1877, vol. xiv, p. 344.