Inborn errors of metabolism: the Croonian lectures delivered before the Royal College of Physicians of London, in June, 1908 / by Archibald E. Garrod.

  • Garrod, Archibald E. (Archibald Edward), Sir, 1857-1936.
Date:
1909
Catalogue details

Licence: In copyright

Credit: Inborn errors of metabolism: the Croonian lectures delivered before the Royal College of Physicians of London, in June, 1908 / by Archibald E. Garrod. Source: Wellcome Collection.

Provider: This material has been provided by Royal College of Physicians, London. The original may be consulted at Royal College of Physicians, London.

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    offers the most likely means of settling the point. That it may be present in early childhood there is abundant evidence to show. The first cystin cal- culus ever examined was taken from the bladder of a cliild of five years. Abderhalden has placed on record the detection of cystinuria in two chil- dren of the same family at the ages of twenty-one months and fourteen months respectively, and Ultzmann the case of a child of two with a cystin calculus who had exhibited symptoms of stone from the age of twelve months. Not a few cases in older children have been described. As affording evi- dence of the long persistence of cystinuria a case which came under the observation of the late Sir Henry Thompson may be quoted, that of an old man, aged eighty-one years, for whom a cystin calculus was crushed, and who had passed a stone of the same nature thirty-nine years previously. There is reason to beheve that cystinuria, Hke alkaptonuria, is occasionally temporary or inter- mittent. No direct evidence of the congenital occurrence of pentosuria, the latest discovered and least known member of the group, is yet forthcoming, and its in- clusion is to be justified on other grounds. That it may persist unchanged for years is certain, but Philosophical Transactions of the Royal Society, 1810, vol. c, p. 223. Zeitschrift fiir physiologische Chemie, 1903, Band xxxviii, p. 657. Wiener medicinische Wochenschrift, 1871, Band xxi, pp. 286, 307. Transactions of the Pathological Society, 1870, vol. xxi, p. 272.