Remarks on Hodgkin's disease / by the late Sir James Galloway, K.B.E., C.B., M.D., consulting physician to Charing Cross Hospital.

  • Galloway, James
Date:
[1922?]
Catalogue details

Licence: In copyright

Credit: Remarks on Hodgkin's disease / by the late Sir James Galloway, K.B.E., C.B., M.D., consulting physician to Charing Cross Hospital. Source: Wellcome Collection.

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    of my late colleague Dr. Ironside Bruce. It seems to be possible in certain cases, and apparently when too rapid resolution of the lymphoid masses takes place under x rays, that very severe reactions with serious rise of temperature and other untoward results may follow the cc-ray exposures. This phenomenon suggests that alien protein poisoning occurs as the result of the breaking down and absorption of the newly formed cells. It must, however, be stated that the tumours of Hodgkin’s disease do not always diminish under x rays. In some cases the application has little or no beneficial effect; it is possible that in these cases much fibrous change has taken place in the glands, so that little beneficial effect from x rays can be expected. References. 1 Hodgkin: Med.-Chir. Trans., 1832, vol. xvii, p. 69. 2 Bright, R.: Guy's Hospital Reports, vols. 2,3, 4, and 5. 3 Wilks, S.: Guy’s Hospital Reports, vols. 26, 37, and 38. 4 Pel, P. K. : Bert. Min. Woch., August, 1887. 6 Ebstein, W.: Ibid., August, 1887. 6 Hall, A. J., and Douglas, J. S. C. : On Relapsing Pyrexia in Lymphadenoma, Quart. Journ. of Med., No. 61, October, 1922. [EDITORIAL COMMENT.] A sad interest attaches to the article on Hodgkin’s disease published this week (p. 1201). Sir James Galloway was pre¬ paring a post-graduate lecture on the subject at the time when he was taken ill, and it was in his mind at the last. The notes he left have, as an act of piety to his friend, been put together by Sir William Hale-White, who has little doubt that the lamented author had intended perhaps to expand the lecture and almost certainly to complete it by some further discussion of the observations and theories he recorded., Even as it stands now it well illustrates Galloway’s qualities as a physician and his attitude towards the more modern methods of studying disease. While he put first clinical observation, coupled in any particular case before him with a consideration of the individual patient, he always had in mind the institutes of medicine, and was ever ready to study tlie suggestions continually flowing from physiology and pathology into the broad stream of medicine. The lecture affords more than one illustration of this. The discovery that the urine in the first case he relates contained a peculiar protein at once aroused his attention. He recognized that it resembled Bence-Jones’s albumin, and sought the expert help of Mr. Sydney W. Cole, who established the fact that the substance was a new protein, differing from Bence-Jones’s albumin in the respects briefly stated in the lecture. We may express the hope that Mr. Cole may shortly publish a fuller account of it, and that other physicians will look out for it in similar cases. Early in his career Galloway had given special attention to diseases of the skin, and the descriptions in this lecture of the cutaneous manifestations to be observed in Hodgkin’s disease are of great value; commonly these manifestations are mentioned only briefly in text books, and yet they may be of very considerable importance. That the pruritus occasionally observed may be so intense as gravely to