Volume 15

Treasury of human inheritance / edited by Karl Pearson, R.A. Fisher, L.S. Penrose.

Date:
1909-
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Treasury of human inheritance / edited by Karl Pearson, R.A. Fisher, L.S. Penrose. Source: Wellcome Collection.

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    The correlation coefficient for age at death in pairs of siblings, affected or unaffected, is low, as can be seen from a glance at Table 8, and equals only 0-151. If we include in the table only those members of the affected sibships who have not manifested the disease the correlation is further reduced • 121 females of affected sibships. O —O Proportionate frequencies of deaths in England and Wales from the Registrar-General’s Report 1930 Diagram 4. Age at death in females of sibships including cases of dystrophia myotonica Table 8. Age at Death in Pairs of Siblings (affected or unaffected)* 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 Totals 5-9 ' 2 1 2 2 3 7 2 1 2 1 3 1 1 — — 28 10-14 1 2 3 — 1 5 1 1 2 2 — 3 — 2 — 23 15-19 2 3 4 3 2 1 3 3 1 3 — 1 — — — 26 20-24 2 — 3 — 5 1 3 3 — 2 — — 1 1 — 21 25-29 3 1 2 5 2 3 8 4 3 8 4 3 7 2 1 56 30-34 7 5 1 1 3 8 4 6 5 7 3 4 1 4 — 59 35-39 2 1 3 3 8 4 6 6 4 5 5 6 2 1 2 58 40^4 1 1 3 3 4 6 6 4 8 8 4 4 :— 2 — 54 45^19 2 2 1 — 3 5 4 8 2 3 9 5 2 — — 46 50-54 1 2 3 2 8 7 5 8 3 10 8 1 1 1 1 61 55-59 3 — — — 4 3 5 4 9 8 2 4 3 1 1 47 60-64 1 3 1 — 3 4 6 4 5 1 4 10 — — — 42 65-69 1 — — 1 7 1 2 — 2 1 3 — 4 2 1 25 70-74 — 2 — 1 2 4 1 2 — 1 1 — 2 2 — 18 75-79 — — — — 1 — 2 — — 1 1 — 1 — — 6 Totals 28 23 26 21 56 59 58 54 46 61 47 42 25 18 6 570 * Omitting those who died before the age of 5 years. to 0-079. We have omitted from this table those who died before the age of 5 years because they constitute a special group with particular underlying causes, and their inclusion would certainly produce a spurious correlation which would bear no relation to that characteristic of deaths at later years. The relatively low correlation for duration of life in siblings belonging to a general population was noted and discussed by Karl Pearson as early as 1901 (Biometrika, I, 50-89). He pointed out the