Non-HLA antigens in health, aging, and malignancy : proceedings of a conference held at Roswell Park Memorial Institute, Buffalo, New York, March 28 and 29, 1983 / editors, Elias Cohen, Dharam P. Singal.

Date:
[1983], ©1983
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Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Credit: Non-HLA antigens in health, aging, and malignancy : proceedings of a conference held at Roswell Park Memorial Institute, Buffalo, New York, March 28 and 29, 1983 / editors, Elias Cohen, Dharam P. Singal. Source: Wellcome Collection.

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    Progress in Clinical and Biological Research Volume 133 NON-HLA ANTIGENS IN HEALTH, AGING, AND MALIGNANCY Proceedings of a conference held at Roswell Park Memorial Institute, Buffalo, New York, March 28 and 29, 1983 Elias Cohen and Dharam P. Singal, Editors The past several years have witnessed a re¬ markable growth of knowledge related to the detection, function, and structure of non-HLA cell surface antigens. Non-HLA Antigens in Health, Aging, and Malignancy documents the progress that has been made regarding non- HLA histocompatibility systems. This volume, which is divided into three sec¬ tions, examines in detail the role of non-HLA antigens in health, aging, and malignancy and transplantation. The first section reviews the role of non-HLA platelet-specific or platelet-associ¬ ated antigens in immune thrombocytopenias, erythrocyte blood group systems that are pres¬ ent on platelets, an immunoenzyme histochemi- cal technique for the simultaneous demon¬ stration of surface antigens on multiple cell types, and alloantigens specific to polymorpho¬ nuclear neutrophils. Chapters in the second section concentrate on the relationship between non-HLA antigens and aging. Topics examined include immuno- genetics and longevity, microhemagglutination- inhibition method for assay of diminution of sialic acid receptors of human platelets, the ability of the immune system of mice in different ages to react in vivo against bacteria, and the antigenic changes observed with cellular aging. The final section focuses on malignancy and transplantation. Specific areas reviewed include non-HLA antigens in breast cancer, how mono¬ clonal antibodies can be used to unravel the intricate immunobiology of chronic lymphatic leukemia, immunodiagnosis of pancreatic can¬ cer, and rejection of normal and malignant tis¬ sue grafts by humoral antibodies. In addition, one chapter describes lymphocytotoxic antibod¬ ies to non-HLA in sera of patients with the ac¬ quired immunodeficiency syndrome (AIDS). Non-HLA Antigens in Health, Aging, and Malignancy will be of value to oncologists, pathologists, immunologists, geneticists, hema- tologists, cell biologists, biochemists, microbiol¬ ogists, and gerontologists. ISBN 0-8451-0133-1 LC 83-13533