On the artificial production of tubercle in the lower animals : a lecture delivered at the Royal College of Physicians, May 15, 1868 / by Wilson Fox.

  • Fox, Wilson, 1831-1887.
Date:
1868
Catalogue details

Licence: Public Domain Mark

Credit: On the artificial production of tubercle in the lower animals : a lecture delivered at the Royal College of Physicians, May 15, 1868 / by Wilson Fox. Source: Wellcome Collection.

Provider: This material has been provided by King’s College London. The original may be consulted at King’s College London.

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    visible drops; sometimes in a finely molecular form. The cl mge is most common towards the centre of the granulations, but is also seen in cells irregularly scattered through ;he adjacent tissue. There may also be sometimes seen in these masses, and in their neigh- bourhood, extraordinary strings and roAVS of cells and nuclei. Sometimes cells apparently, sometimes only nuclei, are visible. The nuclei correspond with those last described. The cells, when visible, are of the type of the smaller round cells; the row or string is contained, apA arently, within some limitary membrane. The size of these 1’oavs is nearly twice or three times that of a capillary. They have no fibrous investment like a vein; no muscular coat like an artery. They suggest to me the idea of a lymphatic tube, swollen either by growth within its interior, or by cells carried into it and obstructing its interior. My own conviction is, that they are lymphatics, filled with a growth of cells (Plate III. fig. 6). When we consider the omentum, I shall have to describe to you structures to which these granulations present, especially in their naked-eye characters, the most striking resemblance. The granulations under the skin are, however, denser; and I have not found them situated in the sheaths of the vessels, as they commonly are in the omentum. The next change of importance is in the lymphatic glands in the neigh- bourhood of the injury—the axillary and the subscapular. They are commonly enlarged to twice or three times their natural size. The changes affecting them are also found in those at a considerable distance, as in the submaxillary, the infraclavicular, and the substernal glands, and in those situated in the course of the trachea. Their apparent number is also increased—that is to say, lymphatic glands of the size of a horse-bean, or even of a kidney-bean, are to be seen where none are visible naturally. On section, they are indurated, semi-transparent, cartilaginous-looking, and shoAving very little distinction between the cortical and medullary substances. Through them are scattered specks, lines, or streaks of cheesy degeneration, of an opaque yellow colour, which are sometimes agglomerated into areas of the size of a pea (Plate I. fig. 5). These sometimes soften into a creamy, diffluent matter, which presents the same granular material and molecular debris which are found in the cheesy masses surrounding the wound. Occasion- ally, most of the lymphatic glands throughout the body may be found to have undergone similar changes. These may be seen in the lumbar, sacral, and inguinal lymphatics, Avitliout any corresponding alterations being found in adjacent parts sufficient to account for the diseased state of the glands. c