A case of Graves' disease with scleroderma and a positive Wassermann reaction, treated with Salvarsan / by H.F.L. Ziegel.

  • Ziegel, Hermann Fred Lange, 1876-
Date:
1913
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Licence: In copyright

Credit: A case of Graves' disease with scleroderma and a positive Wassermann reaction, treated with Salvarsan / by H.F.L. Ziegel. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    the extent of the morphea. Pulse 76. Ars'enic in- ternally continued, now in the form of the Diirck- heimer Maxquelle water, i dram, t.i.d., p.c. April i, 1913; There is noted some further improvement in the skin condition, which is now less than one-third of its extent when first seen by the writer. Bands of normal skin are extending into the affected areas, causing the latter to appear as islands. Most of the nodules disappeared after the salvarsan injec- tions one year and a half ago, and those that re- main are softer and smaller than originally. The patient absolutely refuses any more injections. The weight is now 179 pounds', i.e. a gain of 30 pounds since salvarsan was first given. The pulse fre- quency is 68. There is now very little swelling of the thyroid. Since the salvarsan treatment there has been no recurrence of the headaches, “nervous- nes's,” cardiac palpitation, and difficulty in swallow- ing. April 7, 1913: The luetin test has again been negative. Dr. Howard Fox and the New York Board of Health found the Wassermann negative. Summary and Conclusions.—In a married woman 28 years of age with Graves’ disease complicated with the circumscribed form of scleroderma ^ or morphea the Wassermann reaction was pos'itive. There was no history or clinical evidence of syphilis. In a son 7 years of age and in the husband the Wassermann was negative. Since two intramus- cular injections of s'alvarsan of 0.5 gram each were given one year and nine months ago the Wasser- mann has been negative; moreover, the treatment with arsenobenzol was followed by a gain of 30 pounds in weight, by considerable diminution in the thyroid swelling, by disappearance of the nervous symptoms and the tachycardia, and by marked im- provement in the skin condition. Mos't of the no-