The biochemistry of connective tissue.

London : University of London Audio-Visual Centre, 1976.

1 encoded moving image (43.55 min.) : sound, color.

00:43:55

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Dr Helen Muir,The Kennedy Institute of Rheumatology. Produced by David R Clark. Polarographic strain apparatus by courtesy of Mr M Tuke, Biomechanics Unit, Imperial College. Made by University of London Audio-Visual Centre. Made for British Postgraduate Medical Federation.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Muir introduces the lecture. she shows a table listing different qualities of connective tissue and an illustration of a human finger joint. Muir demonstrates the effect of cartilage on bone by using animated plastic models of the human femoral head. Time start: 00:00:00:00 Time end: 00:06:42:00 Length: 00:06:42:00

Segment 2 Muir shows a slide detailing the diagrammatic representation of cartilage, animaged graphic representation of proteoglycan molecules and electron micrographs of cartilage from the human knee. A further graph is used to show how much water is expressed from cartilage. Time start: 00:06:42:00 Time end: 00:12:57:00 Length: 00:06:15:00

Segment 3 Muir talks about and shows diagrams relating to the structure of cartilage proteoglycans molecules. A graph is shown which compares the size of proteoglycans with other proteins, then a graph showing the effect of proteolytic enzymes on proteoglycans. Time start: 00:12:57:00 Time end: 00:19:57:00 Length: 00:07:00:00

Segment 4 An electron micrograph of proteoglycan aggregates is shown, then graphs showing the relative viscosity of proteoglycan aggregates plotted against hyaluronic acid concentration. A further table is used to summarise the way in which proteoglycans interact with a single chain. Time start: 00:19:57:00 Time end: 00:26:26:00 Length: 00:06:29:00

Segment 5 Muir shows diagrams which detail the stoichiometry of proteoglycan hyaluronic acid reactions. Other graphs show changes in viscosity of proteoglycan hyaluronic acid. Time start: 00:26:26:00 Time end: 00:31:27:00 Length: 00:05:01:00

Segment 6 Muir shows an autoradiograph of molecules. She discusses osteoarthritis. Time start: 00:31:27:00 Time end: 00:38:46:00 Length: 00:07:19:00

Segment 7 Muir shows graphs detailing the development of osteoarthritis and a table listing the main features of osteoarthritis. Time start: 00:38:46:00 Time end: 00:43:55:06 Length: 00:05:09:06