The chemotherapy of experimental amoebiasis.

Young rats are suitable laboratory hosts for caecal infection with Entamoeba histolytica. This film shows the laboratory technique for injecting a concentrated suspension of amoebae into the caecum and the thickened and ulcerated appearance of the caecum a week later. The rats are given regular doses of drugs during the week following inoculation and the amoebicidal activity of the drugs is then assessed by determining what proportion of the rats are amoeba - free after a given dose of the drug.