Clostridium difficile

  • David Goulding, Wellcome Trust Sanger Institute
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Clostridium difficile. David Goulding, Wellcome Trust Sanger Institute. Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Source: Wellcome Collection.

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Clostridium difficile is a major cause of antibiotic-associated diarrheal disease. Part of the reason for it’s persistence in the hospital environment has been ineffective disinfection regimes which have enabled the highly resistant spores to accelerate host transmission. This image illustrates how effectively the vegetative core is protected by three clearly defined coats 100nm thick and an exosporium.

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